Manufactory Supply 114471-18-0 Nesiritide Acetate (BNP-32)99% white powder CAS NO.114471-18-0
Product Description
Nesiritide Acetate (BNP-32) CAS NO: 114471-18-0
Nesiritide is a synthetic human brainnatriureticpeptide (BNChemicalbookP) obtained from Escherichiacoli using recombinant DNA technology, and its effect is very similar to that of human BNP. It contains a 32-amino acid polypeptide, which is joined by a disulfide bond between its l0 and 26th amino acid (both cysteine), forming a ring containing l7 amino acids.
Nesiritide acts after binding to natriuretic peptide A and B receptors. In addition to increasing the production of cGMP, nesilitide also decreased the activity of renin-angiotensin system (RAS) and sympathetic nerve. It has definite dilating effect on the whole body arteriole and venule. It can significantly reduce the pulmonary capillary chock pressure and Chemicalbook right atrial pressure J, and reduce cardiac preload in heart failure. Nesiritide can also significantly reduce the total peripheral vascular resistance, so as to reduce the cardiac afterload in heart failure. It can increase cardiac index, and its mechanism is related to reducing cardiac afterload. It has specific dilating effect on coronary artery. It also has the effect of reducing myocardial oxygen consumption.
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